What does a Lipid Panel with Direct LDL measure? A standard Lipid Panel includes: Total Cholesterol: The total amount of cholesterol in your blood.   HDL Cholesterol (High-density lipoprotein): Often called "good" cholesterol because it helps remove cholesterol from your arteries.   Triglycerides: A type of fat in your blood.   Calculated LDL Cholesterol (Low-density lipoprotein): Often called "bad" cholesterol because high levels can lead to plaque buildup in your arteries.   The "Direct LDL" part is important: Direct LDL: This is a more accurate way to measure LDL cholesterol, especially when triglycerides are high. Traditionally, LDL is often calculated using a formula, which can be less accurate in some cases.   Why is a Lipid Panel with Direct LDL performed? Doctors use this test to: Assess your risk of heart disease. Monitor the effectiveness of cholesterol-lowering medication.   Diagnose conditions that affect cholesterol levels.