What is the hs-CRP test? The hs-CRP test measures very low levels of C-reactive protein (CRP) in your blood. Because it's so sensitive, it can detect even subtle inflammation that might not be picked up by a regular CRP test. What the hs-CRP test is used for: The main use of the hs-CRP test is to: Assess the risk of cardiovascular disease (CVD): Even if you have normal cholesterol levels, a high hs-CRP level can indicate an increased risk of heart attacks, strokes, and other CVD events. It's often used in conjunction with a lipid panel to get a more complete picture of your heart health. It can also be used to: Monitor low-grade chronic inflammation: In conditions like rheumatoid arthritis or lupus. Important Note: Like the regular CRP, a high hs-CRP level doesn't always definitively mean you'll develop heart disease. It's just one risk factor among many.